Why settle for only one technology when you can leverage them all?
Twist Gold Standard
Antibody Discovery is Not One-Size-Fits All
Our Gold Standard workflow is Twist Biopharma Solutions’ flagship service offering. A truly comprehensive, multi-pronged approach to antibody discovery that leverages in vivo, in vitro, and in silico methods in tandem to help maximize your shots on goal and expedite your path to the clinic.
What is a Gold Standard Workflow?
Twist’s Gold Standard workflow brings together the full scope of capabilities from two industry titans, Abveris and Twist Biopharma. Our Gold Standard workflow leverages at least two parallel paths—in vivo and in vitro—or a combination approach (i.e., immune libraries), and leverages in silico methods to bolster the outputs from each path.
In Vivo
1. Single B Cell
In vivo antibody discovery in weeks instead of months powered by the Beacon® Optofluidic System by Berkeley Lights. Advance only antibodies with ideal characteristics by deep screening on Day 1!
2. Hybridoma
Twist's hybridoma engine is powered by our proprietary DiversimAb hyperimmune mouse technology and a high-throughput advanced screening cascade that puts more hybridoma clones in your hands than any other offering.
In Vitro
3. Immune Libraries
Combine the powers of immunization with the customizability of phage display panning. Supercharge your immune libraries using the unrivaled Twist library-building technology and in-house phage display experts. Or, we can build and deliver immune libraries to you.
4. Fully-Human Naïve Libraries
Our fully human naive libraries synthetically mimic the human in vivo antibody repertoire, providing optimal diversity for antibody development against any target. This includes the Hyperimmune Fab, Hyperimmune scFv, Hyperimmune Common Light Chain Fab, and VHH Shuffle Hyperimmune libraries.
Why a Gold Standard Workflow?
Antibody discovery is not a one-size fits all approach and shouldn’t be treated as such. Despite what others may say, every platform has its own inherent limitations and potential risks.
By leveraging multiple pathways simultaneously, our Gold Standard workflow can de-risk campaigns and maximize the chances of identifying desired therapeutic lead candidates. This unrivaled discovery service gives our partners a potentially faster, safer, and more cost-effective path to the clinic.
Key Benefits
Mitigate Risk
Avoid the risk of failure associated with using just one technology.
Best-In-Class
Gain access to all of the industry’s best technologies under one roof for discovery, expression, characterization, and optimization.
Don’t Compromise
With access to industry-leading in vivo, in vitro, and in silico platforms, you don’t need to compromise.
Guaranteed
We value our partners and stand by our work. If we don’t find antibodies specific to your target of interest, we will perform an additional round of discovery for FREE.
Get It Right the First Time
Backed by 10+ years of experience, our team of antibody experts, will work with you every step of the way to guarantee delivery of sequences and/or purified, fully validated, development-ready drug candidates tailored to your
specific program needs.
Choose what discovery platform you would like to explore or work with our antibody enthusiasts to
help decide.
Get in Touch With Us
Antibody enthusiasts are standing by and would love to hear more about your discovery needs. Challenging targets welcome!
