A High-Throughput Platform to Develop Highly Potent and Functional Antibodies against G-protein Coupled Receptors

G-protein coupled receptors (GPCRs) are transmembrane proteins and the targets of a number of small-molecule drugs. Owing to their specificity, half-life, and inability to cross the blood-brain barrier, antibodies are also promising candidates for targeting these receptors. Though there are >500 GPCRs in humans, however, only two approved GPCR antibody-based drugs exist, which highlights the challenges in identifying functional antibodies against this receptor family.