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新产品 DATA 病毒检测 抗体开发 资源
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世界各地的病毒研究与治疗团队都在快速应对最近的冠状病毒疫情。他们需要稳定、可靠的基因组学工具对病毒样本进行分类和鉴定,同时还需要基因组工程工具来制造疫苗,帮助阻止这种致命性病毒的传播。

Twist 独特的硅基 DNA编写平台有助于研究人员快速开发 NGS 组合,用于病毒检测和样本鉴定,同时我们的克隆基因基因片段有助于研究人员快速开发来自一个或多个抗原呈递病毒基因或肽序列的亚单位疫苗,使研究人员无需直接处理具有活性和潜在危险的病原体,同时还能够最大程度缩短克隆DNA 片段所需的时间。

SARS-CoV-2 RNA 合成标准品

阳性标准品为新一代测序 (NGS) 和逆转录聚合酶链式反应 (RT-PCR) 等诊断测试的开发、验证和确认提供了质量控制措施。 

Twist 提供了 2 种完全合成的 SARS-CoV-2 RNA 标准品,分别针对不同的参考序列:

  • Twist SARS-CoV-2 RNA 合成标准品 1 (MT007544.1) - SKU:102019
  • Twist SARS-CoV-2 RNA 合成标准品 2 (MN908947.3) - SKU:102024
相关资源:

SARS-CoV-2 研究组合

除了稳定的 RNA 标准品之外,Twist 还提供仅供研究使用 (RUO) 的靶向富集 NGS 组合,用于病毒检测及样本鉴定。这些组合可应用于环境监测和监控,同时还提供完整的序列信息以监测病毒的进化和病毒株的来源。

  • Twist SARS-CoV-2 研究组合,2 个反应的试剂盒 - SKU:102016
  • Twist SARS-CoV-2 研究组合,12 个反应的试剂盒 - SKU:102017
  • Twist SARS-CoV-2 研究组合,96 个反应的试剂盒 - SKU:102018
相关资源:

如需订购产品,请点击下面的按钮,注册或直接登录账号,进入我们的在线订购平台。.

立刻订购

 

其他资源:

阅读我们关于“创建对抗冠状病毒的原材料”的最新博文

立刻观看:为什么实验室要合成冠状病毒基因组

 

Comprehensive Detection of Respiratory Pathogens
Comprehensive Detection of Respiratory Pathogens
Designed to target multiple viruses in a single capture
Targeted against the reference sequences for 29 common human respiratory viruses
Reliable Detection of Co-Infections
Reliable Detection of Co-Infections
Separate COVID-19 symptoms from those of other respiratory illnesses
Detect and characterize several viruses per reaction
Highly Sensitive at Low Viral Loads
Highly Sensitive at Low Viral Loads
Gather data from nasopharyngeal samples
Detect loads as low as 100 viral copies
DETECT COMMON HUMAN RESPIRATORY VIRUSES

The Twist Respiratory Virus Research Panel is targeted against the reference sequences for 29 common human respiratory viruses, including:

  • Coronavirus (CoV)
  • Influenza virus
  • Adenovirus
  • Bocavirus (hBoV)
  • Enterovirus
  • Metapneumovirus
  • Parainfluenza (hPIV)
  • Human rhinovirus (HRV)
  • Measles morbillivirus (MeV)
  • Mumps virus (MuV)
  • Rubella virus
  • Respiratory syncytial virus (RSV)

Additional probes were designed to incorporate diversity from 77 additional rhinovirus strains, and to target diverse genomes representing each major influenza A and B outbreak since 2000.

Read the App Note

世界各地的病毒研究与治疗团队都在快速应对最近的冠状病毒疫情。他们需要稳定、可靠的基因组学工具对病毒样本进行分类和鉴定,同时还需要基因组工程工具来制造疫苗,帮助阻止这种致命性病毒的传播。

Twist 独特的硅基 DNA编写平台有助于研究人员快速开发 NGS 组合,用于病毒检测和样本鉴定,同时我们的克隆基因基因片段有助于研究人员快速开发来自一个或多个抗原呈递病毒基因或肽序列的亚单位疫苗,使研究人员无需直接处理具有活性和潜在危险的病原体,同时还能够最大程度缩短克隆DNA 片段所需的时间。

SARS-CoV-2 RNA 合成标准品

阳性标准品为新一代测序 (NGS) 和逆转录聚合酶链式反应 (RT-PCR) 等诊断测试的开发、验证和确认提供了质量控制措施。 

Twist 提供了 2 种完全合成的 SARS-CoV-2 RNA 标准品,分别针对不同的参考序列:

  • Twist SARS-CoV-2 RNA 合成标准品 1 (MT007544.1) - SKU:102019
  • Twist SARS-CoV-2 RNA 合成标准品 2 (MN908947.3) - SKU:102024
相关资源:

SARS-CoV-2 研究组合

除了稳定的 RNA 标准品之外,Twist 还提供仅供研究使用 (RUO) 的靶向富集 NGS 组合,用于病毒检测及样本鉴定。这些组合可应用于环境监测和监控,同时还提供完整的序列信息以监测病毒的进化和病毒株的来源。

  • Twist SARS-CoV-2 研究组合,2 个反应的试剂盒 - SKU:102016
  • Twist SARS-CoV-2 研究组合,12 个反应的试剂盒 - SKU:102017
  • Twist SARS-CoV-2 研究组合,96 个反应的试剂盒 - SKU:102018
相关资源:

如需订购产品,请点击下面的按钮,注册或直接登录账号,进入我们的在线订购平台。.

立刻订购

 

其他资源:

阅读我们关于“创建对抗冠状病毒的原材料”的最新博文

立刻观看:为什么实验室要合成冠状病毒基因组

 

Comprehensive Detection of Respiratory Pathogens
Comprehensive Detection of Respiratory Pathogens
Designed to target multiple viruses in a single capture
Targeted against the reference sequences for 29 common human respiratory viruses
Reliable Detection of Co-Infections
Reliable Detection of Co-Infections
Separate COVID-19 symptoms from those of other respiratory illnesses
Detect and characterize several viruses per reaction
Highly Sensitive at Low Viral Loads
Highly Sensitive at Low Viral Loads
Gather data from nasopharyngeal samples
Detect loads as low as 100 viral copies
DETECT COMMON HUMAN RESPIRATORY VIRUSES

The Twist Respiratory Virus Research Panel is targeted against the reference sequences for 29 common human respiratory viruses, including:

  • Coronavirus (CoV)
  • Influenza virus
  • Adenovirus
  • Bocavirus (hBoV)
  • Enterovirus
  • Metapneumovirus
  • Parainfluenza (hPIV)
  • Human rhinovirus (HRV)
  • Measles morbillivirus (MeV)
  • Mumps virus (MuV)
  • Rubella virus
  • Respiratory syncytial virus (RSV)

Additional probes were designed to incorporate diversity from 77 additional rhinovirus strains, and to target diverse genomes representing each major influenza A and B outbreak since 2000.

Read the App Note

DATA
Detect Common Human Respiratory Pathogens with a Single Test

Compiled from the GenBank database, the 41,047 probes in this panel will allow researchers to separate COVID-19 symptoms from those of other respiratory illnesses, both influenza- and non-influenza-related. The Twist Respiratory Panel enables enrichment of these viral sequences for high-resolution NGS. This leads to high-sensitivity detection of as little as 100 copies of viral material with more than 5000x enrichment even from challenging samples, and coverage of > 99.9% of the genome at 1X or greater post-enrichment.

 

NGS-Respiratory-Viral-Controls-Taxonomic-Tree
Detection of viral standards from different viral families

Each Twist Synthetic Viral Control was spiked into 50 ng of human carrier RNA at 1,000,000 copies prior to cDNA synthesis. For each standard, we show percent of on-target viral reads, fold enrichment above input, median coverage across the genome, the percent of bases with at least 30x coverage, and the template length. Viral genomes are ordered by template length (smallest to longest) among all genome segments. In most cases, we found that over 70 percent of reads came from viral genomes in these libraries, representing at least a 2500-fold enrichment over the spiked-in content.

 Detection of viral standards from different viral families
Multiplex for Higher Throughput and Lower Cost

A comparison of the percent on-target viral reads captured using the Twist Synthetic Viral Controls at different viral titers, using a multiplex and single-plex hybridization reaction. The first graph shows comparisons using a multiplex and single-plex hybridization reaction using 1,000,000 copies per library, while the second graph shows a similar comparison using 100, 10,000, and 1,000,000 copies per library. Each viral control was captured using the Twist Standard Target Enrichment workflow and the Twist Respiratory Virus Research Panel. This data demonstrates that 8-plex capture gives comparable efficient enrichment as a single plex capture when using the Twist Respiratory Virus Research Panel.

NGS Respiratory Viral Controls Multiplexing
Detect Common Human Respiratory Pathogens with a Single Test

Compiled from the GenBank database, the 41,047 probes in this panel will allow researchers to separate COVID-19 symptoms from those of other respiratory illnesses, both influenza- and non-influenza-related. The Twist Respiratory Panel enables enrichment of these viral sequences for high-resolution NGS. This leads to high-sensitivity detection of as little as 100 copies of viral material with more than 5000x enrichment even from challenging samples, and coverage of > 99.9% of the genome at 1X or greater post-enrichment.

 

NGS-Respiratory-Viral-Controls-Taxonomic-Tree
Detection of viral standards from different viral families

Each Twist Synthetic Viral Control was spiked into 50 ng of human carrier RNA at 1,000,000 copies prior to cDNA synthesis. For each standard, we show percent of on-target viral reads, fold enrichment above input, median coverage across the genome, the percent of bases with at least 30x coverage, and the template length. Viral genomes are ordered by template length (smallest to longest) among all genome segments. In most cases, we found that over 70 percent of reads came from viral genomes in these libraries, representing at least a 2500-fold enrichment over the spiked-in content.

 Detection of viral standards from different viral families
Multiplex for Higher Throughput and Lower Cost

A comparison of the percent on-target viral reads captured using the Twist Synthetic Viral Controls at different viral titers, using a multiplex and single-plex hybridization reaction. The first graph shows comparisons using a multiplex and single-plex hybridization reaction using 1,000,000 copies per library, while the second graph shows a similar comparison using 100, 10,000, and 1,000,000 copies per library. Each viral control was captured using the Twist Standard Target Enrichment workflow and the Twist Respiratory Virus Research Panel. This data demonstrates that 8-plex capture gives comparable efficient enrichment as a single plex capture when using the Twist Respiratory Virus Research Panel.

NGS Respiratory Viral Controls Multiplexing
病毒检测
One Codex Analysis

Twist Respiratory Virus Research Panel comes with access to the One Codex cloud-based tool. Ideal for research and clinical use, as it can be used to create publication-ready visuals and printable reports for labs preparing laboratory developed tests.

When using the Twist Respiratory Virus Research Panel, the One Codex analysis platform is accessible for all customers. This platform is ideal for both research and clinical use cases, including production of publication-ready visuals, shareable reports, and other analysis tools. When purchasing the panel you will be provided with onboarding instructions and credits for sample analysis on the One Codex platform. Learn more about this microbial sample analysis solution at One Codex.

One Codex User Interface
One Codex Analysis

Twist Respiratory Virus Research Panel comes with access to the One Codex cloud-based tool. Ideal for research and clinical use, as it can be used to create publication-ready visuals and printable reports for labs preparing laboratory developed tests.

When using the Twist Respiratory Virus Research Panel, the One Codex analysis platform is accessible for all customers. This platform is ideal for both research and clinical use cases, including production of publication-ready visuals, shareable reports, and other analysis tools. When purchasing the panel you will be provided with onboarding instructions and credits for sample analysis on the One Codex platform. Learn more about this microbial sample analysis solution at One Codex.

One Codex User Interface
抗体开发
PRODUCT SKUS
103066 Twist Respiratory Virus Research Panel with One Codex software, 2 Reactions, Kit
103067 Twist Respiratory Virus Research Panel with One Codex software, 12 Reactions, Kit
103068 Twist Respiratory Virus Research Panel with One Codex software, 96 Reactions, Kit
SPECIFICATIONS
Format dsDNA
Panel size 41047 probes
Content Based on 29 respiratory virus reference sequences
Desig Databases RefSeq & GenBank
StorageStore at -5 to -30°C
PRODUCT SKUS
103066 Twist Respiratory Virus Research Panel with One Codex software, 2 Reactions, Kit
103067 Twist Respiratory Virus Research Panel with One Codex software, 12 Reactions, Kit
103068 Twist Respiratory Virus Research Panel with One Codex software, 96 Reactions, Kit
SPECIFICATIONS
Format dsDNA
Panel size 41047 probes
Content Based on 29 respiratory virus reference sequences
Desig Databases RefSeq & GenBank
StorageStore at -5 to -30°C
资源