In the last 40 years, advances in protein engineering and evolution have prompted the application of biocatalysts in the synthesis of active pharmaceutical ingredients (API), as well as fine and bulk chemicals for the agrochemical, food, biofuel, and pharmaceutical industries. Computational chemistry methodologies in conjunction with smart variant library generation and high-throughput screening are fueling the development of a new generation of rationally designed biocatalysts with enhanced selectivity and specificity at a fraction of the time and cost of what was achievable a mere decade ago.

游离蛋白表达可以加速合成生物学发现工作。基因片段是产生游离蛋白的最佳底物

获得大量合成 DNA 改变了 Ginkgo Bioworks 的设计-合成-测试-学习循环