混合液协作:冠状病毒免疫治疗联合会 (CoVIC)

混合液协作:冠状病毒免疫治疗联合会 (CoVIC)

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演讲者
Sharon Schendel
Sharon Schendel
La Jolla 免疫学研究所项目经理
RECORDED AT Writing the Future of Infectious Disease

本次网络研讨会中涵盖的内容
7 个合伙实验室对抗体特征进行的分析
一个可分析抗体特征之间关系的公开可用数据库 (CoVIC-DB)

"The Coronavirus Immunotherapeutic Consortium (CoVIC) is an international effort to conduct side-by-side comparisons of therapeutic antibody candidates against SARS-CoV-2 spike originating from multiple sources, such as COVID-19 survivors and in silico design. 
本次网络研讨会的内容介绍:
Analysis by seven partner labs of antibody features including in vivo protection, spike protein affinity, epitope binning, blockage of ACE-2 binding, neutralization of pseudovirus and authentic virus infection, risk of mutagenic escape, and Fc-mediated functions. 
A publicly available database (CoVIC-DB) that allows analysis of relationships among antibody features and can inform selection of potent antibody therapies that are resistant to viral mutagenic escape.   

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