基因
寡核苷酸池
新一代测序 (NGS)
基因突变文库
抗体
IVDR 解决方案
宣传单
产品说明书
案例研究
Twist Bioscience HQ
681 Gateway Blvd
South San Francisco, CA 94080
合成 DNA 技术能够揭秘 G 蛋白偶联受体抗体配体
演讲者
Sean M. Peterson 博士
Staff Scientist, Staff Scientist
本次网络研讨会中涵盖的内容
了解 Twist 合成 DNA 技术如何支持开发精准的抗体以结合 G 蛋白偶联受体。
了解如何使用高通量结合和功能检测来发现具有激动剂和拮抗剂特征的抗体。
了解平行功能筛选如何成功应用于 3 种 GPCR 新型治疗性抗体配体的发现。
Twist synthetic DNA technologies have enabled the development of precision antibody libraries designed to bind to G protein-coupled receptors (GPCRs). We have employed high throughput binding and functional assays to discover antibodies with agonist and antagonist profiles. This parallel functional screening was successfully employed for discovery of novel therapeutic antibody ligands for three GPCRs (called GLP1R, APJR and C5AR1). Twist synthetic DNA technologies allow for the design of novel antibody-based GPCR ligands with profiles for clinical therapeutic development.
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