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Seminario web
Twist Bioscience HQ
681 Gateway Blvd
South San Francisco, CA 94080
Engineering Compact Base Editors: AlphaFold-Guided Design Meets Directed Evolution
Presentado por
Jungjoon Kempthorne Lee Ph.D.
National University of Singapore (NUS), Singapore
Cubierto en este seminario web
Discover how AlphaFold3-guided alanine scanning can identify a single key residue that unlocks a ten-fold improvement in base editing activity
Learn how Trinity-Screen unifies activity, indel reduction, and cytotoxicity selection into one single E. coli workflow
Understand how precise oligo synthesis from Twist Bioscience complements AI-generated models to benchmark base editors with confidence
Join us for an exciting webinar where we dive into a new integrated framework for developing next-generation, compact base editors.
In this webinar, Asst Prof Jungjoon Kempthorne Lee will discuss how his team transformed SsdAtox - a small but inefficient deaminase toxin - into a compact base editor variant that demonstrates substantially improved performance relative to BE4max benchmarks.
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