For AI/ML teams in drug discovery

優れたモデルには優れたデータが必要です

Go from in silico design to physical characterization with Twist.
Get sequence-perfect antibodies, a suite of characterization assays, and AI-ready data in as few as 15 days.

品質の高いデータを
15日で取得

ウェットラボ無しでAIモデルを構築できます。再現性の高いタンパク結合データと、開発適性判断用の物理化学データを短納期で取得。

アッセイ済み抗体数130,000以上
>200,000発現タンパク数
<15 days納期
7,000,000以上生成データポイント数
受注数445 社/大学 以上

Twist提供サービス

Let your team focus on AI,
Twist handles the wet lab.

タンパク質作製、アッセイ、データ生成といった複雑な作業を外注することで、短納期でより多くの配列からモデル用のデータを入手できます。

Power your AI-guided
drug discovery

Twist connects sequence generation to documented,
model-ready data through an integrated suite of products and services.

ステップ 1:設計

配列を送信

生成AIプラットフォームから出力した配列を送信し、ウェットラボ検証用のDNAとタンパク質の製造をスタートさせます。

今すぐご注文
ステップ 2:構築

データ生成

高品質なデータセットを活用すれば、研究者はAIモデルのトレーニングと改良がスムーズにできます。Twist Express Antibodiesとハイスループット特性評価サービスを用いてモデルを検証し、最短15日で配列からデータが取得まで完了。

今すぐご注文
ステップ 3Test

データ納品

Twistは、数千のタンパク質について、結合性および開発適性判断のための物理化学特性データを取得、AI設計配列の検証を可能にします。Twistは、AIおよび機械学習モデルに直接使用できる高品質なデータセットを目的として、臨床用抗体をベンチマークとしたカスタム形式でデータを提供します。

ご相談はこちらから
ステップ 4学習

トレーニングと反復学習

Twistは、配列をモデルへの統合に使える、データセットに結び付け、創薬・開発を支援します。プログラム設計やデータの解釈サポートもご提供します。

ご相談はこちらから

Have custom or complex project needs?

Whether you’re looking for bespoke data configurations or help with MSA contracts, our team is here to help.

お問い合わせはこちら

Why Twist

10+ characterization assays,
all in one workflow

Others can only provide binding confirmation. Twist delivers the full developability picture: every
data type your AI model needs to train, rank, and advance leads to clinical validation.

Binding assessment assays

Developability assays

Cell-based functional assays


Binding kinetics: affinity ranking (SPR)

Pinpoint your top-tier candidates with iso-affinity plots that visualize association and dissociation kinetics, allowing you to instantly rank binders by their KD performance.

Binding kinetics: affinity ranking (SPR) - Pinpoint your top-tier candidates with iso-affinity plots that visualize association and dissociation kinetics, allowing you to instantly rank binders by their KD performance.

On-cell binding confirmation: flow cytometry

Fast, quantitative binding data to validate your best candidates in a cellular context using high-throughput flow cytometry.

On-cell binding confirmation: flow cytometry - Fast, quantitative binding data to validate your best candidates in a cellular context using high-throughput flow cytometry.

Biophysical characterization: epitope binning (SPR)

Map competitive binding relationships to identify epitope diversity and guide lead selection.

Biophysical characterization: epitope binning (SPR) - Map competitive binding relationships to identify epitope diversity and guide lead selection.

開発適性評価:aggregation

Benchmark manufacturing feasibility by quantifying monomeric purity and aggregation levels against clinically validated controls using our comprehensive suite of developability assays.

開発適性評価:aggregation - Benchmark manufacturing feasibility by quantifying monomeric purity and aggregation levels against clinically validated controls using our comprehensive suite of developability assays.

開発適性評価:size distribution

Rapidly assess developability by quantifying particle distribution to help rank order leads with onset of aggregation (Tagg).

開発適性評価:size distribution - Rapidly assess developability by quantifying particle distribution to help rank order leads with onset of aggregation (Tagg).

Thermal stability

Rapidly assess molecule robustness by quantifying thermal stability (Tm).

Thermal stability - Rapidly assess molecule robustness by quantifying thermal stability (Tm).

Off-target binding: BVP-ELISA or AC-SINS

Detect off-target and polyspecific interactions early to de-risk downstream development. The data below are clinical controls we use for benchmarking purposes.

Off-target binding: BVP-ELISA or AC-SINS - Detect off-target and polyspecific interactions early to de-risk downstream development. The data below are clinical controls we use for benchmarking purposes.

Hydrophobicity

Plate-based screening correlated to gold-standard HIC and CIC to enable high-throughput, decision-ready insights.

Hydrophobicity - Plate-based screening correlated to gold-standard HIC and CIC to enable high-throughput, decision-ready insights.

Functional characterization

Customizable assay platforms to evaluate functionality and mechanism of action across multiple cell types.

Functional characterization - Customizable assay platforms to evaluate functionality and mechanism of action across multiple cell types.

Let's talk about your pipeline

Tell us where you are in your AI drug discovery journey. Our scientific team will reach out within one business day to discuss how Twist can accelerate your work.

研究用途に限ります。

診断用には使用できません。

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