In the last 40 years, advances in protein engineering and evolution have prompted the application of biocatalysts in the synthesis of active pharmaceutical ingredients (API), as well as fine and bulk chemicals for the agrochemical, food, biofuel, and pharmaceutical industries. Computational chemistry methodologies in conjunction with smart variant library generation and high-throughput screening are fueling the development of a new generation of rationally designed biocatalysts with enhanced selectivity and specificity at a fraction of the time and cost of what was achievable a mere decade ago.

多様なネイティブ配列と指向性進化を利用して、標的反応における酵素活性を向上させる

ここでご紹介する設計上のヒントによって、遺伝子合成や下流工程実験の成功確率を最大化できます