Don’t Settle for Less
Don’t Settle for Less
Don’t Settle for Less
OVERVIEW DATA CUSTOMIZATION ORDERING & SPECS RESOURCES
OVERVIEW

The NGS Human Core Exome provides the ability to lower sequencing costs, increase sample throughput, and achieve a higher depth of coverage across target regions with uncompromising quality.

Exceptional performance
Exceptional performance
High fidelity double stranded DNA probes with optimized performance
NGS QC of all probes
Uniform enrichment of target regions
Greater flexibility
Greater flexibility
Customization tools allow the rapid and scalable implementation of custom exomes
Modular kit structure enables workflow flexibility for easy integration into existing protocols
Maximized sequencing efficiency
Maximized sequencing efficiency
Increased depth per sample or more samples per run
Lower sequencing costs
EXOME DEFINITION

33 Mb CCDS coverage

99% of ClinVar variants covered

98% of targeted regions covered at 20x with 4.9 Gb

The NGS Human Core Exome provides the ability to lower sequencing costs, increase sample throughput, and achieve a higher depth of coverage across target regions with uncompromising quality.

Exceptional performance
Exceptional performance
High fidelity double stranded DNA probes with optimized performance
NGS QC of all probes
Uniform enrichment of target regions
Greater flexibility
Greater flexibility
Customization tools allow the rapid and scalable implementation of custom exomes
Modular kit structure enables workflow flexibility for easy integration into existing protocols
Maximized sequencing efficiency
Maximized sequencing efficiency
Increased depth per sample or more samples per run
Lower sequencing costs
EXOME DEFINITION

33 Mb CCDS coverage

99% of ClinVar variants covered

98% of targeted regions covered at 20x with 4.9 Gb

DATA
Uncompromised Performance

Twist Human Core Exome Kit resulted in a higher number of targets covered with 20 or 30 reads compared to leading competitors.

Download the Product Sheet

NGS-Fixed-Panel-Human-Comprehensive-Exome-Databases-Venn
Master Deck

Twist Bioscience provides higher library complexity than the competitor kits resulting in a lower duplication rate

NGS-Fixed-Panel-Human-Comprehensive-Exome-TargetCoverage-Graph
Run more samples with the same budget

The improved coverage uniformity of the Twist Human Core Exome reduces the amount of sequencing required to achieve the desired coverage depth

NGS-Fixed-Panel-Human-Comprehensive-Exome-Fold80-Graph
Run more samples with the same budget

The improved coverage uniformity of the Twist Human Core Exome reduces the amount of sequencing required to achieve the desired coverage depth

NGS-Fixed-Panel-Human-Comprehensive-Exome-Databases-Table
Uncompromised Performance

Twist Human Core Exome Kit resulted in a higher number of targets covered with 20 or 30 reads compared to leading competitors.

Download the Product Sheet

NGS-Fixed-Panel-Human-Comprehensive-Exome-Databases-Venn
Master Deck

Twist Bioscience provides higher library complexity than the competitor kits resulting in a lower duplication rate

NGS-Fixed-Panel-Human-Comprehensive-Exome-TargetCoverage-Graph
Run more samples with the same budget

The improved coverage uniformity of the Twist Human Core Exome reduces the amount of sequencing required to achieve the desired coverage depth

NGS-Fixed-Panel-Human-Comprehensive-Exome-Fold80-Graph
Run more samples with the same budget

The improved coverage uniformity of the Twist Human Core Exome reduces the amount of sequencing required to achieve the desired coverage depth

NGS-Fixed-Panel-Human-Comprehensive-Exome-Databases-Table
CUSTOMIZATION
Customization of Core Exome Kit Content and Components

The ability to simply add your spike-in panel to the Core Exome creates added differentiation based on your research requirements. Rapid design optimization with a quick production turnaround reduces overall development time for your custom exome.

  • Additional content with high enrichment uniformity 

  • Increased coverage of specific genes covered by Core Exome 

  • Optimization of spike-in ratio by customer

ustomization of Core Exome Kit Content and Components
Customization of Core Exome Kit Content and Components

The ability to simply add your spike-in panel to the Core Exome creates added differentiation based on your research requirements. Rapid design optimization with a quick production turnaround reduces overall development time for your custom exome.

  • Additional content with high enrichment uniformity 

  • Increased coverage of specific genes covered by Core Exome 

  • Optimization of spike-in ratio by customer

ustomization of Core Exome Kit Content and Components
ORDERING & SPECS
SPECIFICATIONS
Workflow Step Target Enrichment
Format dsDNA
Panel size 33 Mb
Content Human protein coding genes
Design Databases CCDS
Storage Store at -5 to -30°C
SPECIFICATIONS
Workflow Step Target Enrichment
Format dsDNA
Panel size 33 Mb
Content Human protein coding genes
Design Databases CCDS
Storage Store at -5 to -30°C
RESOURCES