This application note describes an end-to-end workflow, beginning with the design of the GPCR 2.0 scFv Library and culminating in the proof-of-concept discovery and characterization of multiple antagonistic, high-affinity, and druglike anti-GLP-1R antibodies. Learn more about the discovery of over a dozen high-affinity antibodies against the GPCR glucagon-like peptide-1 receptor (GLP-1R) from a computationally designed and precisely synthesized Combinatorial Variant Library of GPCR-binding motifs.  See how  Twist Biopharma antibody libraries can yield high-quality antibodies against hard-to-drug targets such as GPCRs.