The Twist Oncology - DNA CGP Panel from Twist Bioscience is designed to enable comprehensive genomic profiling (CGP) of solid tumors for pathogenic variants and scoring of microsatellite instability (MSI) and tumor mutational burden (TMB). QIAGEN CLC Genomics Workbench is a powerful analysis and visualization software with analytical tools and workflows tailored to next-generation sequencing (NGS) data, including data from a wide range of resequencing panel designs. Here, we present highly sensitive somatic detection of commercially available tumor reference samples prepared with the Twist Oncology - DNA CGP Panel and resulting data analyzed with QIAGEN CLC Genomics Workbench.