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Twist Bioscience HQ
681 Gateway Blvd
South San Francisco, CA 94080
Enhancing Therapeutic Properties of a Cancer-Targeting Affibody by Soft Mutagenesis CVL Libraries
See how researchers at the KTH Royal Institute of Technology and Uppsala University are using Twist’s Combinatorial Variant Libraries (CVLs) to engineer previously identified affibody molecules targeting VEGFR2 for basic biological research into the vascularization process and potentially target the treatment of several diseases including cancer and macular degeneration.
Covered in this Application Note
How in silico designed Combinatorial Variant Libraries were used to improve affibody therapeutic properties
Why when undertaking soft mutagenesis, in silico designed CVLs are superior to NNK and trimer libraries
What therapeutic advantages and opportunities affibody molecules offer over monoclonal antibodies
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