SARS-CoV-2, a single-stranded RNA virus, is the cause of the 2019/2020 coronavirus pandemic. Reverse Transcription PCR (RT-PCR) is a rapid method for detecting COVID-19 cases by using primers to amplify regions of interest from the SARS-CoV-2 virus. However, the need also exists for highly sensitive tests capable of characterizing the entire viral genome, including any mutations, to monitor the viral spread and evolution over time. To answer this need, we designed a capture panel that includes probes to target the full SARS-CoV-2 (MN908947.3) reference genome. In this app note we demonstrate detection of as low as 10 copies of viral material with a fold enrichment of >100,000, Coverage of > 99.9% of the genome at 1X or greater after enrichment, and Identification of mutations in the SARS-CoV-2 control MN908947.3.