We’ve built upon Twist’s expertise in utilizing target capture for infectious diseases by creating a panel that is capable of detecting multiple viral pathogens associated with common symptoms of respiratory illnesses. This panel, called the Twist Respiratory Virus Research Panel, is designed to enrich for 29 common respiratory viruses. To validate this panel, we synthesized 15 viral controls, both ssRNA and ssDNA, that were used in addition to the Twist SARS-CoV-2 Synthetic RNA control. These controls were spiked into human reference RNA to generate TruSeq-compatible DNA libraries for target enrichment.