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Application Note
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Optimizing a Candidate Therapeutic Antibody to Optimize Pharmacokinetics using Informed Library Design
See how a leading pharmaceutical company was able to overcome their challenge when developing a high-affinity antibody for the highly-charged interleukin-21 receptor (IL-21R), an important player in the immune system’s cytokine response1.
Covered in this Application Note
Co-crystal structure modeling helps identify potential mutation hotspots
Linear regression model homes in on better antibodies
By using the Combinatorial Variant Library (CVL) Technology in combination with structure-guided library design
Learn how structural modeling identifies key residues for manipulation
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