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Versatile High-Throughput Screening for Transcriptional Repressor Domains Using a Single 300mer Oligo Pool
The ability to generate 300mer oligos is a critical tool for researchers, enabling them to screen more than 70% of sequences identified in PFAM as human nuclear protein domains, which are potential
effectors. Coupled with the exceptional precision, length, and uniformity of Twist Oligos, HT-recruit opens the door to protein domain characterization on a genome-wide scale.
Covered in this Application Note
An annotated nuclear protein domain library
A tiling library of unannotated nuclear protein domains
A deep mutational scanning library of the ZNF10 (KOX1) KRAB domain.
