Removing the DNA bottleneck in antibody discovery

By Dr Aaron Sato, Chief Scientific Officer, Twist Bioscience

The efficiency of candidate antibody discovery pipelines is directly connected to the quality of the DNA library being screened. To reduce discovery timelines, researchers need access to tools allowing them to take more shots on goal, as well as line up these shots effectively. Advances in DNA synthesis technology provide precise antibody variant libraries containing an accurate representation of the designed sequence. Twist Biopharma, a division of Twist Bioscience, utilises these libraries to reduce the candidate antibody discovery cycle down to less than 8 weeks. This workflow was used recently in the discovery of therapeutic antibodies targeting key viral antigens.