Speeding up T-Cell Receptor Discovery for Adoptive Cell Therapy

Adoptive cell therapy arms the patient’s immune system with the tools to fight some of the most challenging and pervasive diseases. Engineered T-cells presenting custom T-Cell Receptors (TCRs) are a promising therapeutic for treating solid tumors. A key challenge in the development of TCR therapeutics is the identification of appropriate TCR binding domains that target disease specific tumor antigens. Twist Bioscience is helping overcome this challenge with combinatorial libraries of alpha and beta domains, allowing researchers to rapidly screen for functional and efficacious TCRs.

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How you can discover precise pairings of variable chains with Twist DNA synthesis

How Twist's Combinatorial library technology underpins effective TCR variable domain screens

How Twist Genes and Oligo pools power the rapid generation of candidate TCRs and antigens

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Genes

Oligo Pools

NGS Target Enrichment Solutions

Variant Libraries

Synthetic Controls

Antibody Discovery

Speeding up T-Cell Receptor Discovery for Adoptive Cell Therapy

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