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Webinar
Twist Bioscience HQ
681 Gateway Blvd
South San Francisco, CA 94080
A High-Throughput Platform to Develop Potent Antibodies against G-protein Coupled Receptors
Presented at PEGS 2019: Twist Bioscience's Gene Synthesis technology allows Twist Biopharma to rapidly identify antibodies against GPCRs
GPCRs are well-studied and many ligands and peptides that bind to this family have already been identified, so one approach to tackling this challenge is to incorporate these natural binding partners into an antibody library design. We describe here the construction of a GPCR-focused phage-display antibody library. By mining GPCR binding ligands and peptides and incorporating their sequences into the heavy chain CDR3, we developed a design for identifying functional antibodies to a range of GPCR targets.
