Long-read capture with Twist target enrichment system

Targeted sequencing allows for high-resolution characterization of gene regions at a scale and cost that is more accessible than whole genome sequencing. Here we describe a method to leverage Twist Bioscience target enrichment workflow for gene panels sequenced with HiFi reads. This poster presents the content and the performance of two Twist Alliance panels, pharmacogenomics panel with the Twist Human Mitochondrial Panel and a nearly 400-gene panel of challenging “dark genes” relevant to human health.


Covered in this Poster
Target enrichment with PacBio long and accurate HiFi reads
Design strategy and target list for PGx and Dark Genes Alliance Panels
Performance data and gene tracks for each panel
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