In this poster, we demonstrate Twist's target enrichment systems as a sensitive and informative approach combining library preparation and 30 minute Fast Hybridization for detecting viral agents that can be RNA or DNA as well as single- or double-stranded. The data show that our SARS-CoV-2 Research Panel can detect the virus with as few as 10 copies of SARS-CoV-2 genome. Extending our results beyond single infections, the data demonstrate that Twist’s Respiratory Virus Research Panel simultaneously detects multiple viral agents which can then be sequenced with excellent coverage in a model of co-infection.