Combinatorial Assembly Libraries

For comprehensive screening of user defined combinations of custom gene parts

Twist’s state-of-the-art DNA synthesis platform streamlines the development of advanced cell therapies by enabling the creation of large-scale, highly diverse T-cell Receptor (TCR), chimeric antigen receptor (CAR), and multispecific VHH libraries. Through combinatorial assembly, Twist generates highly uniform screening libraries with precise, user-defined combinations of gene fragments, enabling efficient and comprehensive screening of the desired combinations of custom gene parts, such as domains from TCRs, CARs, or antibody VHH/scFv fragments.