The COVID-19 pandemic has led to a rapid and collaborative response from the scientific community. Research teams are in need of reliable genomic tools to characterize samples including viral co-infections. SARS-CoV-2 infection leads to a range of symptoms that can vary drastically between subjects. This makes it hard to determine if those symptoms are strictly SARS-CoV-2-related, the result of a different respiratory pathogen(s), or a combination of the two. The Twist Respiratory Virus Research Panel makes detecting a comprehensive range of pathogens possible, allowing researchers to not only accurately detect the cause(s) of a subject’s symptoms, but to also characterize the responsible viral pathogens.