The Twist for Element Trinity, Exome 2.0 + Comprehensive Spike, Standard Hyb Workflow kit provides the reagents needed to prepare genomic DNA (gDNA) libraries using enzymatic gDNA fragmentation and the Twist Universal Adapter System - Element Compatible. The Twist Universal Adapter System – Element Compatible consists of Twist Universal Adapters - Element Compatible and Twist UDI Primers – Element Compatible. This manual details the steps for generating the amplified, indexed libraries and performing a target enrichment workflow. The resulting enriched DNA library can be sequenced on Element next-generation sequencing (NGS) systems using the Trinity sequencing workflow.