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Solid-Phase DNA Synthesis Allows Tight Control of Combinatorial Library Quality and Diversity
Explore how Twist's DNA synthesis produces Combinatorial Libraries of superior quality compared to other library generation technologies
Combinatorial DNA libraries are essential to modern protein research. In this article, we present the most commonly used approaches and technologies available for combinatorial library synthesis and explain their associated codon bias, amino acid distribution, error rate, yield, library diversity, and quality. We demonstrate that Twist Bioscience’s proprietary silicon-based solid-phase technology stands apart with its impressive ability to offer high throughput and low cost while enabling tight control of library quality and diversity.
Covered in this Technical Note
Methods for library generation by oligonucleotide synthesis
Key factors affecting library quality
How choice of library synthesis method affects library diversity
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