The symptoms for SARS-CoV-2 are similar to other diverse viral pathogens resulting in respiratory illnesses. As influenza season approaches, there is a push to develop assays capable of detecting more than one pathogen in a single test, which would allow for rapid pathogen identification without lengthy systematic testing to rule out individual pathogens. With a multiplexed assay comes the need for an increased set of diverse viral controls. In this tech note we demonstrate the compatibility of the diverse Twist Respiratory Viral controls as positive controls for the Twist Respiratory Virus Research Panel. We also demonstrate that these same viral controls serve as useful negative controls for routine SARS-CoV-2 testing.