Through the production of highly specific antibodies, plasma cells (PCs) and their progenitors plasmablasts (PBs) are essential for acute and long-term host protection against infection. While several transcription factors are known to be essential for PC and PB differentiation and survival, many more remain to be elucidated. To address this issue, Dr. Miriam Wöhner and co-workers at the Research Institute of Molecular Pathology (IMP) in Austria, performed targeted CRISPR-Cas9 screening of over 3,000 genes to assess their impact on PB development. *Results from customer experiences are not predictive of results in other cases. Results in other cases may vary.