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Twist Bioscience HQ
681 Gateway Blvd
South San Francisco, CA 94080
De Novo Design of G Protein Mimetics
De Novo Design of G Protein Mimetics
Presented by
Chris Bahl
Institute of Protein Innovation
RECORDED AT Writing the Future of Drug Discovery
Covered in this Webinar
How tools to stabilize the active conformational state of GPCRs will facilitate protein purification and structure determination
How using de novo protein design, the Bahl lab have developed novel Galpha mimetic proteins
Data showing these are thermostable, selectively bind to the active state of GPCRs, & can bind to a wide range of different GPCRs
Generalizable tools to stabilize the active conformational state of GPCRs will facilitate protein purification and structure determination, as well as accelerate the engineering of molecules which act as agonists or antagonists. Using de novo protein design, we have developed novel Galpha mimetic proteins that are thermostable, selectively bind to the active state of GPCRs, and can bind to a wide range of different GPCRs
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