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Twist Bioscience HQ
681 Gateway Blvd
South San Francisco, CA 94080
Harnessing the diversity of CRISPR-Cas proteins for genome editing
Presented by
Dr. Giedrius Gasiunas
CasZyme
Covered in this Webinar
See the wide range of activities that this set of programmable nucleases demonstrate in vitro and in the cellular environment
Discuss the natural diversity of Cas proteins as a source of novel gene editing tools
The efficiency and ease of use of the CRISPR-Cas9 system has led to its rapid adoption as a robust and versatile genome editing tool. However, limitations remain - not least the constraint of the Cas9 protospacer adjacent motif (PAM), which limits the locations that can be targeted.
One way to overcome this is to explore the natural variation afforded by other CRISPR-associated (Cas) enzymes - which provide a rich resource for the development of RNA-guided genome editing tools with diverse and potentially beneficial properties.
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