In Silico Accelerated Antibody Characterization

MabSilico Astrid Musnier

alt text
Presented by
Astrid Musnier
Astrid Musnier
MabSilico
RECORDED AT Writing the Future of Drug Discovery

Covered in this Webinar
Discussion of use of therapeutic antibodies for gynaecology and endocrinology.
Using MAbTope, its in silico epitope mapping tool, MAbSilico was able to characterize GlycoFormA antibody.
Twist Bioscience technology was used to generate the FSH constructs which were used to validate the prediction in its wet-lab

Therapeutic antibodies are used mostly in oncology and auto-immune diseases, but they are not used yet in gynaecology and endocrinology, where the absence of suitable markers for reproductive aging in women is a growing problem as families start at later parental ages. Follicle-stimulating hormone (FSH) glycosylation is a predicator of fertility treatment success. GlycoFormA Ltd. developed an anti-FSH antibody specific of a deglycosylated FSH isoform. Using MAbTope, its in silico epitope mapping tool, MAbSilico was able to characterize GlycoFormA antibody. Twist Bioscience technology was used to generate the FSH constructs which were used to validate the prediction in its wet-lab facility.

Share your details to Watch the Webinar