Synthetic DNA Technologies Enable the Discovery of G Protein-Coupled Receptor Antibody Ligands

Presented by

Dr. Sean M. Peterson

Covered in this Webinar

Learn how Twist synthetic DNA technologies enable the development of precision antibody to bind to G protein-coupled receptors.

See how high throughput binding and functional assays were used to discover antibodies with agonist and antagonist profiles.

Hear how parallel functional screening was successfully employed for discovery of novel therapeutic antibody ligands for 3 GPCRs.

Twist synthetic DNA technologies have enabled the development of precision antibody libraries designed to bind to G protein-coupled receptors (GPCRs). We have employed high throughput binding and functional assays to discover antibodies with agonist and antagonist profiles. This parallel functional screening was successfully employed for discovery of novel therapeutic antibody ligands for three GPCRs (called GLP1R, APJR and C5AR1). Twist synthetic DNA technologies allow for the design of novel antibody-based GPCR ligands with profiles for clinical therapeutic development.

Share your details to Watch the Webinar

Genes

Oligo Pools

NGS Target Enrichment Solutions

Variant Libraries

Synthetic Controls

Antibody Discovery

Synthetic DNA Technologies Enable the Discovery of G Protein-Coupled Receptor Antibody Ligands

Related Resources

Finding Improved Biologics with Twist’s Machine Learning and Deep Learning Tools

Combinatorial Assembly Libraries

Accelerated Antibody Discovery Targeting a Cell Surface Receptor using a Beacon-Based Single B Cell Workflow