Modern therapeutic targets are getting more challenging while traditional, single modality platforms are no longer sufficient on their own. Twist Biopharma Solutions offers a comprehensive "discovery trifecta" for antibody development, uniting the strengths of two leading providers to deliver in vivo, in vitro, and in silico discovery services—all under one roof. In this presentation, we will discuss case studies highlighting the discovery and pre-clinical validation of antibody candidates targeting immunology and oncology-related diseases. We will introduce our latest advancements in single B cell workflows and offer insights into building effective display libraries by leveraging structure-guided machine learning and diverse immune source populations for optimal results.