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Research Square, Dec 2021 DOI:
10.21203/rs.3.rs-1179128/v1

11C-metomidate PET CT versus Adrenal Vein Sampling for diagnosing surgically curable primary aldosteronism: prospective test validation, and impact of somatic genotype and ethnicity on outcomes

Wu, Xilin; Senanayake, Russell; Goodchild, Emily; Bashari, Waiel; Salsbury, Jackie; Cabrera, Claudia; Argentesi, Giulia; O'Toole, Samuel; Matson, Matthew; Koo, Brendan; Parvanta, Laila; Hilliard, Nick; Kosmoliaptsis, Vasilis; Marker, Alison; Berney, Daniel; Wen, Wilson Tan Lek; Foo, Roger; Mein, Charles; Wozniak, Eva; Savage, Emmanuel; Sahdev, Anju; Bird, Nicholas; Laycock, Kate; Boros, Istvan; Hader, Stefan; Warnes, Victoria; Gillett, Dan; Dawnay, Anne; Adeyeye, Elizabeth; Prete, Alessandro; Taylor, Angela; Arlt, Wiebke; Bhuva, Anish; Aigbirhio, Franklin; Manisty, Charlotte; McIntosh, Alasdair; McConnachie, Alex; Cruickshank, J. Kennedy; Cheow, Heok; Gurnell, Mark; Drake, William; Brown, Morris
Product Used
NGS
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Abstract
Primary aldosteronism (PA) due to a unilateral aldosterone-producing adenoma (APA) is a common, curable cause of hypertension, but invasive methods of diagnosis and treatment contribute to -17%, the pre-specified margin of non-inferiority. The best univariate predictors of complete clinical cure were home systolic blood pressure (SBP)
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Product Used
NGS

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