Custom Panels Product Page | Twist Bioscience

Overview

Target Exactly What Matters

Twist Custom NGS Panels let you move beyond off-the-shelf solutions, giving you full control over what you sequence. Our proprietary design strategies, developed by expert bioinformaticians, power high-performance enrichment across DNA, RNA, and methylation applications. Target exactly what matters—with precision, flexibility, and performance built in.

Target Exactly What Matters

Twist Custom NGS Panels let you move beyond off-the-shelf solutions, giving you full control over what you sequence. Our proprietary design strategies, developed by expert bioinformaticians, power high-performance enrichment across DNA, RNA, and methylation applications. Target exactly what matters—with precision, flexibility, and performance built in.

Key Benefits

Exceptional performance

Twist double-stranded probes achieve uniform, high on-target coverage even in GC-rich and complex regions.

Straightforward customization

Easily design a panel around your unique genes, pathways, or variants through our online tools or with an expert.

Higher resolution

Capture rare variants, copy number variations (CNVs), or low-frequency events that arrays often miss.

Smarter spend

Reduce sequencing waste and cost by avoiding low-performing panels or overspending on whole genome approaches.

See how Twist Custom NGS Panels work.

How does Twist make every read count? Resolution.

Traditional Barriers with Other Panels	Twist Solutions
Uneven coverage and GC bias leading to missed variants or dropouts	Precision probe synthesis ensures balanced coverage across GC-rich and complex regions, leading to fewer dropouts
Probe redundancy and off-target capture wasting reads and budget	Exon-aware, junction-spanning design captures isoforms, fusions, and hard-to-reach exons
Complex splicing and isoform diversity missed by rigid, pre-designed panels	Uniform, reproducible data reduces revalidation cycles and speeds time to confident results

Smarter Designs, Better Data

DNA

Get the genomic data you need with a custom DNA target enrichment panel. Utilizing innovative strategies, such as our probe shifter technology, we ensure the highest performance and precision in your custom panels.

Start Design

Download White Glove DNA Submission Form

RNA

Capture transcriptomic data with a customized RNA panel - designed to capture and enrich libraries converted to cDNA. Our team utilizes novel RNA design strategies, such as exon-aware placement, to provide you with the transcriptomic insights you need.

Download White Glove RNA Submission Form

METHYLATION

Capture methylation data with a custom DNA methylation panel. Twist’s novel design approach achieves high uniformity and retains the methylation pattern by printing four different probe species for each target: fully methylated, fully unmethylated, sense, and antisense probes.

Download White Glove Methylation Submission Form

Highlighted applications

Cancer Research

In applications like liquid biopsy minimal residual disease (MRD) testing, off-the-shelf panels often fall short. This example from IntegraGen shows how Twist Custom NGS Panels enabled high sensitivity and scalability for liquid biopsy–based cancer monitoring.

LEARN MORE

Highlighted applications

Agrigenomics

Polyploid genomes are common in many agricultural plant species, making genomic analysis complex. In this webinar, HudsonAlpha demonstrates how Twist Custom Panels offer an efficient, cost-effective approach to investigate complex genomes and scale AgBio breeding programs.

SEE HOW

Highlighted applications

Hereditary Disease Research

By combining Twist’s Enzymatic Fragmentation library prep and full-length adapters with Element Biosciences’ Avidite Base Chemistry, this PCR-free, hybrid-capture approach eliminates amplification bias and preserves native repeat structure, even across GC-rich or unstable regions. The result: high-fidelity detection of both normal and expanded alleles — including difficult loci such as DMPK (22/84 repeats) — while saving up to five hours of hands-on time compared with traditional workflows.

SEE HOW

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What Scientists Have to Say

“

Twist sales may make absurd claims about how good Twist Custom Panels are, but we have found no reason to dispute those claims. We didn’t believe it until we ran their panel ourselves. Our last run had an average uniformity of 99.5%, meaning that you can drop your average coverage right down. We’ve basically doubled the number of samples we can fit on a run.

MARK DAVIS, Ph.D.

Scientist, Neurogenetics Unit, Department of Diagnostic Genomics PathWest Laboratory Medicine, Australia

“

Other companies were cutting costs and focusing more on fitting everything into one box rather than working with customers to devise custom probes that fit their highly specific research needs. Twist bucked the trend.”

Download Infographic

LYDIA SMITH

Evolutionary Genetics Lab Manager, UC Berkeley

“

Twist’s Custom Panels allowed us to focus on important, medically relevant genes instead of forcing us to work with a whole genome. The panel was concise, with a simple protocol and cost was reasonable with very good candidate variants already curated by the literature.”

RENATA PELLEGRINO

PhD Technical Director at Philadephia Research Center

* Results from customer experience are not predictive of other cases. Results in other cases may vary.