Your Targets, Your Design, On Your Schedule
Your Targets, Your Design, On Your Schedule
Your Targets, Your Design, On Your Schedule
OVERVIEW DATA ORDERING RESOURCES
OVERVIEW

At Twist Bioscience, we combine precise oligonucleotide synthesis with a scalable silicon-based manufacturing platform to generate high-performing probe panels for NGS target enrichment.

We also complement this powerful technology with proprietary design algorithms and a rapid iteration pipeline to enable the quick design, synthesis, and optimization of custom panels.

Twist Custom Panels can be designed and built to cover a wide range of panel sizes, target regions, and multiplexing requirements — all with exceptional and consistent performance.

Whether you design your own panel from scratch or add targets to enhance the content of existing panels, you can use your Twist Custom Panel with Twist’s modular library preparation kits or seamlessly integrate them into an existing workflow.

Exceptional performance
Exceptional, Consistent Performance
Effective design, accurate synthesis, and detailed quality control maximize both uniformity of capture and reproducibility
High-fidelity double-stranded DNA probes offer high-quality, consistent performance
NGS-based quality control of all probes ensures balanced probe representation and minimizes dropout
Customization
Rapid Customization and Optimization
Fast turnaround time to final panel
Simple addition or enhancement of content without sacrificing performance
Ensures adjustment of workflow biases for optimum performance
Scalable
Intuitive, Proprietary Panel Design
Scalable design from 100 to >1M probes per pool
Reduces the iterations to final design
Enables balanced capture, even for challenging regions

At Twist Bioscience, we combine precise oligonucleotide synthesis with a scalable silicon-based manufacturing platform to generate high-performing probe panels for NGS target enrichment.

We also complement this powerful technology with proprietary design algorithms and a rapid iteration pipeline to enable the quick design, synthesis, and optimization of custom panels.

Twist Custom Panels can be designed and built to cover a wide range of panel sizes, target regions, and multiplexing requirements — all with exceptional and consistent performance.

Whether you design your own panel from scratch or add targets to enhance the content of existing panels, you can use your Twist Custom Panel with Twist’s modular library preparation kits or seamlessly integrate them into an existing workflow.

Exceptional performance
Exceptional, Consistent Performance
Effective design, accurate synthesis, and detailed quality control maximize both uniformity of capture and reproducibility
High-fidelity double-stranded DNA probes offer high-quality, consistent performance
NGS-based quality control of all probes ensures balanced probe representation and minimizes dropout
Customization
Rapid Customization and Optimization
Fast turnaround time to final panel
Simple addition or enhancement of content without sacrificing performance
Ensures adjustment of workflow biases for optimum performance
Scalable
Intuitive, Proprietary Panel Design
Scalable design from 100 to >1M probes per pool
Reduces the iterations to final design
Enables balanced capture, even for challenging regions
DATA
Consistent Performance Across a Range of Panel Sizes and Target Regions

Design a Twist Custom Panel in minutes using a list of gene names or a target bed file. Regardless of panel size or target region, Twist Custom Panels consistently deliver excellent performance.

NGS Custom Panel Design Summary Table
Robust Performance During Multiplex Target Enrichment

Twist Custom Panels deliver high-quality performance across 1-, 8-, and even 16-plex enrichment reactions:

  • High uniformity for all levels of multiplexing
  • High on-target rates do not vary with higher levels of multiplexing
  • Low duplication rates across all levels of multiplexing

 

NGS Custom Panel Performance Picard Metrics
Verified by NGS to Ensure Reproducibility from Lot to Lot

As demonstrated by NGS-based quality analysis, Twist Custom Panels demonstrate a low lot-to-lot variation. Every Twist Custom Panel is sequenced to ensure consistent quality and performance across all probes within a panel.

 

NGS Custom Panel C800Lot NGSQC Scatter log10 LowRun
Consistent Performance Across a Range of Panel Sizes and Target Regions

Design a Twist Custom Panel in minutes using a list of gene names or a target bed file. Regardless of panel size or target region, Twist Custom Panels consistently deliver excellent performance.

NGS Custom Panel Design Summary Table
Robust Performance During Multiplex Target Enrichment

Twist Custom Panels deliver high-quality performance across 1-, 8-, and even 16-plex enrichment reactions:

  • High uniformity for all levels of multiplexing
  • High on-target rates do not vary with higher levels of multiplexing
  • Low duplication rates across all levels of multiplexing

 

NGS Custom Panel Performance Picard Metrics
Verified by NGS to Ensure Reproducibility from Lot to Lot

As demonstrated by NGS-based quality analysis, Twist Custom Panels demonstrate a low lot-to-lot variation. Every Twist Custom Panel is sequenced to ensure consistent quality and performance across all probes within a panel.

 

NGS Custom Panel C800Lot NGSQC Scatter log10 LowRun
ORDERING
Rapid Customization, Easy Ordering

Twist Bioscience is the leader in cost-effective, scalable oligonucleotide synthesis. We help you design your custom panel and then quickly build it for you at the scale you choose. Once you test the panel in your own lab using the workflow of your choice, we work with you to quickly revise the panel design or simply scale up its production to meet your needs. Simply contact Twist Bioscience at sales@twistbioscience.com for more information.

 

Rapid Customization, Easy Ordering

The Twist Custom Panels are for research use only, and subject to additional use restrictions as set forth in Twist’s Supply Terms and Conditions.

Rapid Customization, Easy Ordering

Twist Bioscience is the leader in cost-effective, scalable oligonucleotide synthesis. We help you design your custom panel and then quickly build it for you at the scale you choose. Once you test the panel in your own lab using the workflow of your choice, we work with you to quickly revise the panel design or simply scale up its production to meet your needs. Simply contact Twist Bioscience at sales@twistbioscience.com for more information.

 

Rapid Customization, Easy Ordering

The Twist Custom Panels are for research use only, and subject to additional use restrictions as set forth in Twist’s Supply Terms and Conditions.

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