Antibody Production & Characterization

High-throughput antibodies from DNA to data

Get more shots on goal with industrial speed and consistent, reproducible yields. We combine high-velocity workflows with comprehensive data to accelerate your iterative discovery cycles.

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From sequence to validated candidates. All in one workflow.

Production that keeps pace with your pipeline

Move from sequence to purified protein in as few as 10 business days. With an industrial capacity of 6,000+ IgGs per week, we deliver the scalability and speed required to keep your discovery timeline on track.

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Characterize your antibodies with confidence

Get decision-ready data without the downstream delay. We integrate advanced characterization; including binding, purity, and stability, directly into our high-throughput workflow. Identify your best leads at the speed of your discovery.

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Data optimized for AI and ML integration

Let Twist handle the wet lab while your team focuses on AI. We deliver high-fidelity, model-ready datasets at industrial scale to fuel your discovery pipelines. Get the high-velocity, structured characterization your team needs to rank, train, and optimize candidates with confidence.

Explore AI drug discovery

Antibody Production Services

Produce your antibodies.
Propel your discovery.

High-throughput workflow

What to expect

Cell line options

Choose the right expression system for your discovery

From fast HEK-based screening to scalable CHO-based development.

HEK293

Lightning-fast discovery

  • Best for: Early screening and hit ID
  • Key advantage: Maximum speed and adaptability
  • Turnaround: Starting at 10 business days*
  • Price: Starting at $102 per purified IgG
CHO

The gold standard for Biopharma

  • Best for: Therapeutic leads and scale-up
  • Key advantage: Established regulatory track record
  • Turnaround: Starting at 13 business days*
  • Price: Starting at $102 per purified IgG
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Purification options

One platform, two paths to purification

His-Tagged (Ni-IMAC)

  • Best for scFv, Fab, VHH, and recombinant proteins
  • Very small (6xHis) tag that minimizes structural interference with the protein
  • Optimized for rapid affinity ranking and cell-based binding confirmation

Fc-Tagged (Protein A)

  • Best for full-length IgG and VHH-Fc formats
  • Large tag aids in protein solubility, stability, and proper folding
  • Move directly into high-sensitivity multi-point KD determination

Characterization Services

Characterization data in as few as 15 business days

Binding assessment

Find your top binders

Screen large panels to identify antibodies with the strongest and most specific binding. Choose from binding confirmation, affinity, kinetics, and epitope binning.

Find your top binders
Identify your most stable and manufacturable candidates

Developability

Identify your most stable and manufacturable candidates

Advance promising candidates with drug-like developability profiles to reduce downstream manufacturing and clinical failure risk.

Advanced characterization

Go deeper with advanced characterization

Format and profile your proteins and antibodies for functional data with add-on and custom assay development options.

Go deeper with advanced characterization

Applications

Versatility for any discovery application

AI/ML model training

Generate the standardized, high-volume datasets required to validate platforms and train predictive discovery algorithms.

Biotherapeutic development

Scale your biologic research with high-throughput discovery of therapeutic and tool antibodies.

Diagnostic research & reagent discovery

Accelerate your path from DNA to data with flexible screening of candidate leads for diagnostic and reagent development programs.

Your next innovation

Access specialized protein engineering expertise, high-throughput production, and advanced characterization without the need for internal lab space or infrastructure investment.

Why choose Twist?

One end-to-end trusted partner

Antibody production and characterization delivered with the same quality and reliability you expect from Twist.

Scalable from one to thousands

Whether you're running a few candidates or thousands for AI model training, Twist's high-throughput infrastructure supports consistent turnaround and performance at any volume.

Scientific expertise

Work directly with scientists to design and analyze your data from defining project scope, to screening set-up and interpreting data results.

Outsource with confidence

Twist serves as your external R&D engine, giving you access to precision and expertise without the need to invest in internal equipment, lab space, or staffing.

Our antibodies and services are just one part of the workflow

Pair our high-throughput antibodies and services with a full range of versatile Twist solutions.

Get matched with an expert

Collaborate with a trusted scientific partner to guide your project specs. From bespoke data configurations to workflow design, our experts provide the proactive support you need to reduce friction at every step.

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