Iterate your AI models without bottlenecks with reproducible binding and developability in weeks
The challenge
AI-based discovery teams often encounter three problems when bridging the gap from code to biology. Only Twist has the specialized capabilities to solve all three:
Who we serve
Whether you're building the next foundation model or advancing a clinical lead, Twist has a path for you.
Twist connects sequence generation to documented, model-ready data through an integrated suite of products and services.
Input your sequences from your Gen AI platforms to generate DNA or protein production for wet-lab validation.
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With high-quality datasets, researchers can train and refine their AI models. Validate those models with Twist Express Antibodies and high-throughput characterization services to generate data from sequences in as few as 20 days.
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Twist enables the validation of your AI outputs for thousands of proteins for binding and developability characteristics. Twist offers custom data delivery formats that are benchmarked against clinical antibody controls to ensure high-quality datasets ready for direct use in your AI and machine learning models.
Speak to an expert
Twist connects your sequences to documented and predictable data sets that you can use to integrate into your models improve your drug discovery and development efforts. Need help designing a program or interpreting your data?
Speak to an expertWhy Twist
Others can only provide binding confirmation. Twist delivers the full developability picture: every data type your AI model needs to train, rank, and advance leads to clinical validation.
Full kinetic characterization across a concentration series with global $K_D$ fits (Blue: data; Red: fit).
Assess biophysical properties including thermal stability (Tm, Tagg), self-association (AC-SINS), and hydrophobicity (HIC) to de-risk lead solubility and aggregation.
Identify antibody communities and distinct binding epitopes via classical SPR cross-competition for diverse lead selection.
Benchmark manufacturing feasibility and sample quality by quantifying production yield, monomeric purity (aSEC), and particle size distribution (DLS).
Assess biophysical properties including thermal stability (Tm, Tagg), self-association (AC-SINS), and hydrophobicity (HIC) to de-risk lead solubility and aggregation.
Evaluate developability and pharmacokinetic risk by quantifying off-target binding and self-association via BVP-ELISA and CIC profiling.
Quantify monovalent affinity and selectivity via SPR, integrated with full developability profiling across both binders and non-binders.
Validate antagonistic function and signaling activity through high-throughput cAMP, Beta-arrestin recruitment, and PBMC activation assays.
Tell us where you are in your AI drug discovery journey. Our scientific team will reach out within one business day to discuss how Twist can accelerate your work.
For Research Use Only. Not for use in diagnostic procedures.
Twist Bioscience HQ
681 Gateway Blvd
South San Francisco, CA 94080
Genes
Oligo Pools
NGS
Variant Libraries
Synthetic Controls
Antibody Discovery
IVDR Solutions
