Writing the Future of Antibody Engineering

Unlocking the potential of antibody improvement has never been more exciting. With Twist Bioscience's innovative DNA writing technologies, we're redefining what's possible in antibody discovery and development. 

At Twist Biopharma Solutions, we’re revolutionizing antibody engineering and optimization with high-throughput, silicon-based technology to enable rapid, precise creation of custom antibody libraries tailored to enhancing your therapeutic antibody candidates. Complemented by our AI/ML engine and state-of-the-art antibody characterization capabilities, we can deliver antibody candidates with the greatest chance of clinical success. Learn more about how our partnership can empower your biotherapeutics breakthroughs and beyond.

Key Features

Unmatched Scale
Speed and Efficiency
Diversity and Precision
Iterative Optimization

The Twist Antibody Optimization (TAO) Toolbox at your Fingertips

Discover more with a comprehensive suite of tools and services for antibody engineering and optimization. Our TAO platform offers the scientific expertise of our antibody engineers with innovative technologies to accelerate your biologic discovery and development.

Custom Library Generation

Simply input your murine, chimeric, humanized, or fully human antibody sequence, and our algorithm will optimize and humanize it into a “human repertoire-inspired” phage display library.

  • pH-Dependent Binding
  • Liability Mitigation
  • Improve Biophysical Properties
  • Optimize Kinetic Profile
  • Strengthen IP Filings or FTO Lockdown

In Silico Humanization

An add-on or stand-alone service to engineer fully-human antibodies while maintaining desired affinity, safety, and efficacy profiles.

  • Species Cross-Reactivity
  • Liability Mitigation





AI/ML-Assisted Language Model Affinity Maturation

Rapid, high-diversity in silico library screening to deliver you a selection of antibody variants with improved affinity profile.

  • Affinity Maturation
  • Liability Mitigation
  • Improve Biophysical Properties



Are you looking for a specific application or interested in designing a
custom program with our antibody engineers?

Speak with an Expert

What Scientists Have to Say

Twist is the only synthetic DNA provider who can deliver the quantity and quality of DNA we need for our projects rapidly. We are working with them not only as a vendor for synthetic genes and antibodies, but have expanded our relationship to leverage the Twist Biopharma capabilities, which we believe complement our antibody discovery efforts.”




Associate Director of the Vanderbilt Vaccine Center

Our platform rapidly generates and validates new targets for treating challenging cancers. Working with Abveris will enable us to quickly identify and select highly specific antibodies for those targets, so that we can take the best antibody forward to address the needs of particular patient populations.”




Immunitas Therapeutics

Explore More

Explore Twist Biopharma Solution’s integrated antibody discovery and development services to support
your program from concept to clinic.

Twist’s Gold Standard in Antibody Discovery

Product SheetAntibodies

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Twist Express Antibody Production

Product SheetAntibodies

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Antibody Characterization and Developability


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Get in Touch With Us

Antibody enthusiasts are standing by and would love to hear more about your discovery needs. Challenging targets welcome!