Twist Bioscience HQ
681 Gateway Blvd
South San Francisco, CA 94080
Get more shots on goal with industrial speed and consistent, reproducible yields.
From sequence to validated candidates
Production that keeps up
Move from sequence to purified protein in as few as 5 business days, at industrial scale.
Explore production services
Characterize with confidence
Get decision-ready data integrated directly into your production workflow.
Explore characterization services
Optimized for AI/ML
Get the datasets so your team can focus on the models while Twist handles the wet lab.
Explore AI drug discoveryAntibody Production Services
Produce your antibodies.
Propel your discovery.
Protein in 5 business days
Antibodies in as few as 5 business days with cell-free antibodies, 10 business days for HEK293, and 13 for CHO.
Reproducibility at any scale
Eliminate variability with our silicon platform. Scale discovery across the biological continuum.
Broad format coverage
IgG, bispecifics, VHHs, Fabs, scFvs, and recombinant proteins in human, mouse, and rabbit isotypes.
Configured for your program
Format, cell line, expression scale, purification, delivery, and QC are all configurable to your program, not a fixed menu.
What to expect
From submission to antibody
Sequence submission
Submit full-length or single-chain antibody sequences and select your preferred options.
Start
Gene synthesis & cloning
Genes are synthesized, cloned into selected vector, and DNA is prepared for transfection.
5 – 7 business days
IgG expression & purification
Paired chains or single chains are transfected in mammalian cells, harvested, then purified.
4 days (HEK293)
6 days (CHO)
1 day (Cell-free)
6 days (CHO)
1 day (Cell-free)
Quality control
Purified proteins are quantified and inspected for size and purity.
1 – 2 business days
Downstream processing
Select buffer exchange, normalization, and 0.2µm filtration if desired.
1 business day
Project completion
Antibodies are shipped after passing QC.
Total turnaround time:
8 – 11 business days (HEK293)
11 – 14 business days (CHO)
5 business days (Cell-free)
8 – 11 business days (HEK293)
11 – 14 business days (CHO)
5 business days (Cell-free)
Expression system options
Choose your expression system
HEK293
Discovery with maximum speed and adaptability, for early screening and hit ID
Turnaround
From 8 business days*
Price
Starting at $127 per purified IgG
CHO
The gold standard for biopharma, for therapeutic leads and scale-up
Turnaround
From 11 business days*
Price
Starting at $127 per purified IgG
Coming soon
Cell-free
Full-length antibodies at cell-free speed, for high-throughput screening at scale
Turnaround
5 business days*
Price
Starting at $87.75 per variant
Compare specifications
Choose your purification option
His-Tagged (Ni-IMAC)
Minimal-interference tag for fast affinity ranking of scFvs, Fabs, VHHs, and recombinant proteins.
Fc-Tagged (Protein A)
Stability-boosting tag to move full-length IgG and VHH-Fc into high-sensitivity KD determination.
CH1 Domain (Anti-CH1 Resin)
One-step bispecific purification that enables in-format discovery, no reformatting required.
Characterization Services
Characterization data in as few as 8 business days
Binding assessment
Find your top binders
Screen large panels to identify antibodies with the strongest and most specific binding. Choose from binding confirmation, affinity, kinetics, and epitope binning.
+ Explore binding options
Developability
Identify your most stable and manufacturable candidates
Assess thermal stability via nanoDSF, predict aggregation and solubility with aSEC, AC-SINS, and DLS, and minimize off-target liabilities with polyreactivity and CIC screens — all in one integrated workflow.
+ Explore developability profiles
Advanced characterization
Go deeper with advanced characterization
Verify molecular weight via intact mass spec, ensure suitability for sensitive assays with endotoxin testing, and assess cross-reactivity and specificity across species models.
+ Explore advanced capabilities
Applications
Versatility for any discovery application
AI/ML model training
Generate the standardized, high-volume datasets required to validate platforms and train predictive discovery algorithms.
Biotherapeutic development
Scale your biologic research with high-throughput production of therapeutic candidates or tool antibodies.
Diagnostic & reagent discovery
Accelerate your path from DNA to data with flexible screening of candidate leads.
Protein engineering innovation
Access specialized protein engineering expertise, high-throughput production, and advanced characterization.
Proteins in action
Success stories and studies featuring Twist Antibodies
Deep Repertoire Mining Uncovers Ultra-Broad Coronavirus-Neutralizing Antibodies
9,000+
Antibodies identified
239
Antibodies expressed and characterized at scale
Discover how high-throughput antibody production and SPR-based epitope binning enabled researchers to mine ultra-rare, broadly neutralizing coronavirus antibodies from recovered and vaccinated patient samples.
Products used
High Throughput Antibodies Affinity Ranking, Epitope Binning
Deep Repertoire Mining Uncovers Ultra-Broad Coronavirus-Neutralizing Antibodies
Get to Characterization Data in a Matter of Weeks Without Making a Single Protein
10+
Characterization assays available
<15 days
Turnaround time
Discover how Twist's end-to-end antibody production and characterization platform delivers high-quality, structured datasets across binding, developability, and advanced characterization, without a wet lab.
Products used
High Throughput Antibodies Binding Assessment, Developability, Advanced Characterization Codon Optimization
Get to Characterization Data in a Matter of Weeks Without Making a Single Protein
From Sequences to Systems: Designing a Next-Gen Wet Lab
3 weeks
Experimental cycle time
2x
More high-affinity binders identified vs. traditional methods
Discover how pairing Twist's high-throughput antibody production and characterization with Cradle's generative AI platform creates a seamless make-test cycle; cutting experimental timelines to three weeks and surfacing more high-affinity leads faster.
Products used
High Throughput Antibodies
From Sequences to Systems: Designing a Next-Gen Wet Lab
1/3
Why choose Twist?
The support to go further
Your trusted partner
Antibody production and characterization delivered with the same quality and reliability you expect from Twist.
Scalable to thousands
Twist’s high-throughput infrastructure supports consistent turnaround and performance at any volume.
Scientific expertise
Get scientific guidance from defining project scope, to screening set-up and interpreting data..
Your external team
Add capacity and expertise without the need to invest in internal equipment, lab space, or staffing.
Extend your workflow
Pair our antibodies and services with a full range of versatile Twist solutions.
Antibody Discovery Services
Partner with our team of experts to navigate the entire discovery funnel from target to lead.
Explore
Oligo Pools
High-diversity, silicon-synthesized oligo pools designed for high-throughput screening and complex library construction.
Explore
Libraries
Explore vast sequence space with high-diversity libraries where every variant is base-by-base synthesized and NGS-verified to match your design.
Explore
Genes
Explore vast sequence space with high-diversity libraries where every variant is base-by-base synthesized and NGS-verified to match your design.
ExploreConsult with an expert
Collaborate with a scientific partner to guide your project specs. From bespoke data configurations to workflow design, get the support you need to reduce friction at every step.
For Research Use Only.
Not for Diagnostic Procedures.
Turnaround time (TAT) is defined as the period from order submission to delivery, in business days: HEK293 8–11 BD, CHO 11–14 BD, Cell-free 5 BD. All pricing in USD. Stated times reflect the fastest available configuration; actual TAT varies with format, order size and sequence complexity.Connect with an expert
