Unleashing Precision in Clinical Genomics

Whole exome sequencing (WES) has become crucial in clinical practice, enabling a comprehensive approach to identifying genomic variants that may contribute to a diagnosis or guide treatment decisions. With greater efficiency than whole genome sequencing and broad coverage over protein-coding sequences, WES can be an ideal tool for genomic analyses.

Twist’s Whole Exome Library Preparation Solution for Clinical Settings

Introducing Twist’s Precision Dx Products — a whole exome library preparation and target enrichment workflow with IVDR certification.

This suite of products includes:

• Twist Precision Prep and Enrichment Dx Kit: Reagents for enzymatic fragmentation, library preparation, and target enrichment.
• Twist Precision Exome Dx Kit: Reagents for enzymatic fragmentation, library preparation, and target enrichment along with targeted capture probes for exome enrichment.
• Twist Precision Exome Dx Panel: Targeted capture probes for exome enrichment.

The Twist Precision Prep and Enrichment Dx Kit and the Twist Precision Exome Dx Panel products can be purchased individually or they can be ordered as a complete solution, which is the Twist Precision Exome Dx Kit.

The Twist Precision Exome Dx Products are intended for use with high-quality genomic DNA derived from human cells such as whole blood, ultimately producing exome-enriched libraries compatible with Next-Generation Sequencing (NGS) applications. The Twist Precision Dx Product offers an EU IVDR-compliant solution with proven performance. 

The Twist Precision Exome Dx Kit has demonstrated effective performance in several quality metrics. Additionally, Twist is collaborating with Platomics to enable laboratories to efficiently generate documentation on Platomics’ multi-stakeholder platform for workflows incorporating the Twist Precision Exome Dx Kit and help automate regulatory processes and accelerate compliance for laboratories and manufacturers. End users will be required to perform additional validation when integrating the Twist Precision Dx Products for diagnostic applications.

For in vitro diagnostic use. Not available in all regions and countries.

*Panels supplied by users must meet Twist specifications, available upon request