Publications
Molecular cancer, Oct 2024 |
23
 (
1
),
221
 DOI:
10.1186/s12943-024-02134-4

Deciphering resistance mechanisms in cancer: final report of MATCH-R study with a focus on molecular drivers and PDX development

Vasseur, Damien; Bigot, Ludovic; Beshiri, Kristi; Flórez-Arango, Juan; Facchinetti, Francesco; Hollebecque, Antoine; Tselikas, Lambros; Aldea, Mihaela; Blanc-Durand, Felix; Gazzah, Anas; Planchard, David; Lacroix, Ludovic; Pata-Merci, Noémie; Nobre, Catline; Da Silva, Alice; Nicotra, Claudio; Ngo-Camus, Maud; Braye, Floriane; Nikolaev, Sergey I; Michiels, Stefan; Jules-Clement, Gérôme; Olaussen, Ken André; André, Fabrice; Scoazec, Jean-Yves; Barlesi, Fabrice; Ponce, Santiago; Soria, Jean-Charles; Besse, Benjamin; Loriot, Yohann; Friboulet, Luc
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Abstract
Understanding the resistance mechanisms of tumor is crucial for advancing cancer therapies. The prospective MATCH-R trial (NCT02517892), led by Gustave Roussy, aimed to characterize resistance mechanisms to cancer treatments through molecular analysis of fresh tumor biopsies. This report presents the genomic data analysis of the MATCH-R study conducted from 2015 to 2022 and focuses on targeted therapies.The study included resistant metastatic patients (pts) who accepted an image-guided tumor biopsy. After evaluation of tumor content (TC) in frozen tissue biopsies, targeted NGS (10 
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Product Used
Genes

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