The front cover picture shows symbolically a high‐throughput silicon‐chip‐based DNA solid‐phase synthetic platform (background) for preparing a library of DNA mutants that encode epoxide hydrolase (center) variants. Massive sequencing revealed that 97 % of the theoretically possible DNA mutants were formed, compared to only 56 % when applying conventional saturation mutagenesis. The DNA synthetic approach is also superior at the protein level, with many stereoselective variants that were missed in the saturation mutagenesis library being identified. The picture was prepared by Gillian Jarvis and Aitao Li. More information can be found in the full paper by M. T. Reetz et al. o