Publications
Communications biology, Mar 2023 |
6
 (
1
),
277
 DOI:
10.1038/s42003-023-04589-5

From a genome-wide screen of RNAi molecules against SARS-CoV-2 to a validated broad-spectrum and potent prophylaxis

Yogev, Ohad; Weissbrod, Omer; Battistoni, Giorgia; Bressan, Dario; Naamati, Adi; Falciatori, Ilaria; Berkyurek, Ahmet Can; Rasnic, Roni; Izuagbe, Rhys; Hosmillo, Myra; Ilan, Shaul; Grossman, Iris; McCormick, Lauren; Honeycutt, Christopher Cole; Johnston, Timothy; Gagne, Matthew; Douek, Daniel C; Goodfellow, Ian; Hannon, Gregory James; Erlich, Yaniv
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Abstract
Expanding the arsenal of prophylactic approaches against SARS-CoV-2 is of utmost importance, specifically those strategies that are resistant to antigenic drift in Spike. Here, we conducted a screen of over 16,000 RNAi triggers against the SARS-CoV-2 genome, using a massively parallel assay to identify hyper-potent siRNAs. We selected Ten candidates for in vitro validation and found five siRNAs that exhibited hyper-potent activity (IC50 
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Oligo Pools

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