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American journal of hematology, Apr 2024 DOI:
10.1002/ajh.27306

Involvement of the JAK-STAT pathway in the molecular landscape of tyrosine kinase fusion-negative hypereosinophilic syndromes: A nationwide CEREO study

Groh, Matthieu; Fenwarth, Laurène; Labro, Mathilde; Boudry, Augustin; Fournier, Elise; Wemeau, Mathieu; Marceau-Renaut, Alice; Daltro de Oliveira, Rafael; Abraham, Julie; Barry, Marly; Blanche, Philippe; Bodard, Quentin; Braun, Thorsten; Chebrek, Safia; Decamp, Matthieu; Durel, Cécile-Audrey; Forcade, Edouard; Gerfaud-Valentin, Mathieu; Golfier, Camille; Gourguechon, Clément; Grardel, Nathalie; Kosmider, Olivier; Martis, Nihal; Melboucy Belkhir, Sarah; Merabet, Fatiha; Michon, Adrien; Moreau, Stéphane; Morice, Cécile; Néel, Antoine; Nicolini, Franck E; Pascal, Laurent; Pasquier, Florence; Pieragostini, Andrea; Roche-Lestienne, Catherine; Rousselot, Philippe; Terriou, Louis; Thiebaut-Bertrand, Anne; Viallard, Jean-François; Preudhomme, Claude; Kahn, Jean-Emmanuel; Lefevre, Guillaume; Duployez, Nicolas; CEREO Collaborators,
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Abstract
We investigated using a custom NGS panel of 149 genes the mutational landscape of 64 consecutive adult patients with tyrosine kinase fusion-negative hypereosinophilia (HE)/hypereosinophilic syndrome (HES) harboring features suggestive of myeloid neoplasm. At least one mutation was reported in 50/64 (78%) patients (compared to 8/44 (18%) patients with idiopathic HE/HES/HEUS used as controls; p 
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