Molecular classifications enhance prognostic accuracy in meningiomas; however, their predictive significance following stereotactic radiosurgery (SRS) remains unclear. This study aimed to assess whether molecular characteristics identified by whole-exome sequencing (WES), specifically driver mutations and copy number alterations (CNAs), are prognostic indicators of outcomes after SRS. This retrospective cohort study included 95 patients (median age 61; 66% female) with 97 surgically resected meningiomas treated with SRS between 1999 and 2023. Primary outcomes were progression-free survival (PFS) and disease-specific survival (DSS). Tumors were molecularly classified using WES into Group A (NF2-wildtype), Group B (NF2 mutation/22q loss without high-risk CNAs), and Group C (high-risk CNAs including 1p loss, 1q gain, 6p/6q loss, 10p/10q loss, 14q loss, 18p/18q loss, and CDKN2A/B homozygous deletion). Group C exhibited significantly inferior PFS at 5 years (49.7%) compared with Groups A (88.5%, p