Of all the events (from six WHO Regions), 15% were associated with the European Region. The annual proportion varied such as 8% in 2007 and 22% in 2022. Events’ classification by hazards and syndromes showed infectious (89%) and acute respiratory syndromes (42%) as the most common causes. Per annex-2 of the IHR (2005), about 88% and 66% of events qualified for unusual/unexpected or serious public health impact respectively and 60% simultaneously qualified both the criteria. About 61% of events qualified for unusual/unexpected and having risk of international spread concurrently. Similarly, 55% events had risk of international spread and serious public health impact, simultaneously. About 16% had risk of interference with international travel/trade. The recent EIS communications (2019-2022) were related to monkeypox, COVID-19, hepatitis of unknown aetiology, human influenza caused by a new subtype and polio.