We thank R. B. Grossman and C. L. Schardl for helpful discussions. We acknowledge the BioPACIFIC MIP (NSF Materials Innovation Platform, DMR-1933487) at the University of California, Santa Barbara for access to instrumentation. This work is supported by the start-up funds from the University of California, Santa Barbara and partially supported by a research grant from the ACS GCI Pharmaceutical Roundtable. We thank G. Wu for small-molecule X-ray structure determinations. We thank the beamline staff at SSRL BL9-2 for assistance with remote data collection on protein crystal diffractions. Use of the Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, is supported by the US Department of Energy, Office of Science, Office of Basic Energy Sciences under contract number DE-AC02-76SF00515. The SSRL Structural Molecular Biology Program is supported by the DOE Office of Biological and Environmental Research and by the National Institutes of Health, National Institute of General Medical Sciences (including P41GM103393). The work at Lawrence Livermore National Laboratory was performed under the auspices of the US Department of Energy by Lawrence Livermore National Laboratory under contract number DE-AC52-07NA27344.