The ability to obtain transcriptomic, genomic, and other omic insights at the resolution level of individual cells has revolutionized biological discovery. Examining genomes and transcriptomes at single-cell resolution exposes ever-increasing degrees of cellular heterogeneity that are masked when performing bulk sequencing. This has provided new understanding of gene expression subpopulations within a sample, aided reconstruction of clonal evolution, and guided mechanistic hypotheses for drug-resistant persister cells. Despite this, adoption of single-cell genomic sequencing has lagged behind single-cell transcriptional analysis, largely because of the expense of whole genome sequencing (WGS) that increases with number of single cells sequenced.