Genes
Oligo Pools
NGS
Variant Libraries
Synthetic Controls
Antibody Discovery
IVDR Solutions
Protocol
Twist Bioscience HQ
681 Gateway Blvd
South San Francisco, CA 94080
Twist UMI Adapter System
Enhanced sensitivity for rare variant detection .
Low-input sample sources, such as cfDNA, are increasingly common in the research and development of potential cancer diagnostic tools. Sequencing analysis of these sample types requires robust methods to confidently detect low frequency alleles. In these cases, unique molecular identifiers (UMIs) may be added to the standard NGS workflow. UMIs offer increased sensitivity in quantitative variant identification where the data may be impacted by confounding PCR duplicates.
