A novel coronavirus disease (COVID-19) burst into a pandemic due to the severe respiratory syndrome coronavirus (SARS-CoV-2) infection. Facial coverage in public has been a common demand made by almost all governments. The shortage of medical masks with the higher price and more significant respiratory resistance causing accidents made many people prefer homemade facial covers with fabrics rather than medical masks. This scenario calls for a method to enhance the SARS-CoV-2 filtration efficiency of the homemade masks. Based on our former research of B. subtilis secreting the protein with cellulose-binding domain (CBD) as a platform, which is highly stable after the binding, we proved the concept of an efficiency enhancer spray for homemade masks to capture SARS-CoV-2. This research developed a workflow of genetically replacing the updated SARS-CoV-2 antibody binding domain onto CBD, expressing the target protein, and testing the efficiency enhancement of the cellulose capturing the target domain of SARS-CoV-2. In summary, our work took advantage of the easy assembly feature of synthetic biology to suggest a relief solution for pandemic control.